Across TCGA cell cohorts, TUBB mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TUBB-associated genes across cancer lineages are MAGEB10, PRAMEF20, and PLA2G4D. Each is linked with TUBB in more than 1 cancer types. Because this analysis shows association rather than direction, both TUBB-to-partner and partner-to-TUBB results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUBB→partner) and Y-score (partner→TUBB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB10 →	+0.087	+3.930	<.001	.003	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.012	+4.437	<.001	.004	3	1
BLOOD_Leukemia	PLA2G4D →	+0.040	+4.254	.003	.007	3	1
BLOOD_Leukemia	OR1N2 →	+0.018	+3.705	.008	.007	3	1
BLOOD_Leukemia	FIGLA →	+0.022	+4.984	<.001	.002	3	1
BLOOD_Leukemia	EBF2 →	+0.327	+3.999	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

TUBB survival (RNA) · tumor vs normal (RNA) · all TUBB data types