TUBA4B

Across TCGA patient cohorts, TUBA4B mutation is significantly associated with the RNA expression of many other genes, with 643 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TUBA4B-associated genes across cancer lineages are GRPEL2P2, MIR544A, and CYP4F36P. Each is linked with TUBA4B in more than 2 cancer types. Because this analysis shows association rather than direction, both TUBA4B-to-partner and partner-to-TUBA4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GRPEL2P2 grouped by TUBA4B-low versus TUBA4B-high in SARC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUBA4B→partner) and Y-score (partner→TUBA4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SARC	GRPEL2P2 →	+0.084	+4.954	<.001	.004	3	3
SKCM	MIR544A →	+0.329	+7.232	<.001	<.001	3	2
LUSC	CYP4F36P →	+0.205	+4.978	<.001	.005	3	2
UCEC	MIR6857 →	+0.238	+2.452	.002	.008	3	2
SARC	RN7SKP222 →	+0.131	+5.152	<.001	.003	3	2
SARC	IGHD4-4 →	+0.985	+4.778	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 643 associations by consensus.

GRPEL2P2 by TUBA4B expression — SARC

Explore this box plot interactively →