TUBA4A

Across TCGA patient cohorts, TUBA4A mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TUBA4A-associated genes across cancer lineages are eIF4E, JNK2, and Ku80. Each is linked with TUBA4A in more than 1 cancer types. Because this analysis shows association rather than direction, both TUBA4A-to-partner and partner-to-TUBA4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by TUBA4A-low versus TUBA4A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUBA4A→partner) and Y-score (partner→TUBA4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.212	+2.013	.005	.016	3	1
UCEC	JNK2 →	+0.228	+1.584	.001	.019	3	1
UCEC	Ku80 →	+0.182	+1.594	.032	.042	3	1
UCEC	MEK1 →	+0.400	+2.415	.002	.003	3	1
UCEC	NF-kB-p65_pS536 →	-0.374	-2.321	.022	.033	3	1
UCEC	p62 Lck ligand →	+0.385	+2.321	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

eIF4E by TUBA4A expression — UCEC

Explore this box plot interactively →