TUBA4A

Across TCGA pan-cancer cohorts, TUBA4A RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated TUBA4A data layer compared with 3 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TUBA4A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TUBA4A expression acts as an unfavorable survival marker, although some lineages such as UCS and KIRC show a favorable association.

LUAD, MESO, and LIHC are the cancer types where TUBA4A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.267	0.426	.001	82	view →
MESO	OS	Median	All	0.419	0.661	<.001	62	view →
LIHC	OS	Tertile	All	0.564	0.761	<.001	45	view →
UCS	DFS	Median	All	0.642	0.383	.011	36	view →
LAML	DFS	Quartile	All	0.376	0.768	.002	28	view →
PAAD	DFS	Quartile	All	0.305	0.581	.004	26	view →
KIRC	DFS	Quartile	II,III,IV	0.618	0.229	.007	24	view →
GBM	OS	Median	All	0.271	0.554	<.001	21	view →
KIRP	DFS	Quartile	II,III,IV	0.249	0.715	.006	21	view →
THCA	OS	Median	II,III,IV	0.979	0.775	.009	18	view →
OV	OS	Quartile	IV	0.255	0.495	.024	16	view →
HNSC	DFS	Tertile	IV	0.566	0.731	.011	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

TUBA4A–LUAD (DFS)

Open the LUAD breakdown →