TUBA1C

Across TCGA pan-cancer cohorts, TUBA1C RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated TUBA1C data layer compared with 4 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher TUBA1C RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TUBA1C expression acts as an unfavorable survival marker, although some lineages such as READ and COAD show a favorable association.

MESO, KICH, and LIHC are the cancer types where TUBA1C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.422	0.680	<.001	129	view →
KICH	DFS	Median	II,III,IV	0.649	1.000	<.001	111	view →
LIHC	OS	Median	All	0.598	0.770	<.001	90	view →
KIRC	OS	Median	II,III,IV	0.452	0.649	.002	74	view →
BRCA	OS	Median	II,III,IV	0.877	0.944	<.001	69	view →
SKCM	OS	Tertile	All	0.282	0.435	<.001	59	view →
PAAD	DFS	Tertile	All	0.198	0.497	<.001	53	view →
LGG	OS	Median	All	0.743	0.879	<.001	45	view →
READ	OS	Median	III,IV	0.916	0.327	.004	39	view →
LUAD	OS	Quartile	All	0.559	0.733	<.001	35	view →
COAD	OS	Quartile	All	0.743	0.446	.001	34	view →
SARC	DFS	Tertile	All	0.523	0.709	.001	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

TUBA1C–MESO (OS)

Open the MESO breakdown →