TUBA1C

Across TCGA pan-cancer cohorts, TUBA1C mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TUBA1C data layer compared with 29 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher TUBA1C mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TUBA1C expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

CCRCC, HNSC, and GBM are the cancer types where TUBA1C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	III,IV	0.485	0.854	.007	40	view →
HNSC	DFS	Quartile	III,IV	0.972	0.651	.002	23	view →
GBM	OS	Median	All	0.281	0.490	.011	8	view →
PDAC	DFS	Tertile	IV	0.203	0.752	.024	5	view →
LSCC	OS	Tertile	All	1.000	0.960	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TUBA1C–CCRCC (OS)

Open the CCRCC breakdown →