TUBA1B

Across TCGA patient cohorts, TUBA1B mutation is significantly associated with the RNA expression of many other genes, with 1,463 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TUBA1B-associated genes across cancer lineages are IGLJ6, IGHD6-13, and BPNT2P. Each is linked with TUBA1B in more than 1 cancer types. Because this analysis shows association rather than direction, both TUBA1B-to-partner and partner-to-TUBA1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGLJ6 grouped by TUBA1B-low versus TUBA1B-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUBA1B→partner) and Y-score (partner→TUBA1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	IGLJ6 →	+0.500	+3.345	<.001	.008	3	2
CESC	IGHD6-13 →	+0.922	+3.646	.004	.001	3	2
SKCM	BPNT2P →	+0.073	+3.491	<.001	.003	3	2
BLCA	RNU6-675P →	+0.352	+7.640	<.001	.009	3	2
UCEC	RN7SKP214 →	+0.234	+2.334	<.001	<.001	3	2
UCEC	KRTAP20-3 →	+0.058	+3.890	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,463 associations by consensus.

IGLJ6 by TUBA1B expression — CESC

Explore this box plot interactively →