TTYH2

Across TCGA patient cohorts, TTYH2 mutation is significantly associated with the RNA expression of many other genes, with 3,190 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTYH2-associated genes across cancer lineages are LINC02414, IGHV3OR16-8, and TTTY12. Each is linked with TTYH2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TTYH2-to-partner and partner-to-TTYH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02414 grouped by TTYH2-low versus TTYH2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTYH2→partner) and Y-score (partner→TTYH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	LINC02414 →	+0.160	+3.785	<.001	.004	3	3
LGG	IGHV3OR16-8 →	+0.253	+4.602	<.001	.008	3	2
CESC	TTTY12 →	+0.039	+4.812	<.001	.006	3	2
CESC	SNORD3C →	+0.054	+4.812	<.001	.006	3	2
LUAD	TRGV11 →	+0.127	+4.116	<.001	.004	3	2
BLCA	RNU6-1228P →	+0.188	+4.122	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,190 associations by consensus.

LINC02414 by TTYH2 expression — LUSC

Explore this box plot interactively →