Q-omics provides the consensus-scored TTTY15 profile across patient tissues and cancer cell-line models. TTTY15 expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, TTTY15 is differentially expressed in 8, with the highest sampling consensus in KICH. Additionally, TTTY15 RNA expression shows 8,256 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight HNSC, KICH, and TGCT as cancer lineages where TTTY15 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for TTTY15 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes TTTY15 survival associations across molecular data types. TTTY15 RNA expression shows survival associations in the most cancer types (21). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible TTTY15 RNA expression–survival associations across cancer types. High TTTY15 expression shows unfavorable associations in MESO and READ, but favorable associations in HNSC, UVM, OV and KIRC. The HNSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify HNSC as the clearest survival context for TTTY15 RNA expression.
This table summarizes TTTY15 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 8. The strongest signals are observed in KIRP for RNA.
This table ranks reproducible tumor–normal expression differences for TTTY15. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. TTTY15 shows lower tumor expression in KICH, KIRP, READ and THCA and higher tumor expression in CHOL and PRAD. The KICH box plot shows higher TTTY15 RNA expression in normal versus tumor tissue (log2 FC = −1.628, t-test p = .001).
This table shows molecular features associated with TTTY15 in patient tissues and cancer cell lines. In patient samples, TTTY15 shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set.
