TTTY1

Across TCGA patient cohorts, TTTY1 RNA expression is significantly associated with the mutation status of many other genes, with 138 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible TTTY1-associated genes across cancer lineages are MICAL1, CSTF1, and KCNMA1. Each is linked with TTTY1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTTY1-to-partner and partner-to-TTTY1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MICAL1 grouped by TTTY1-low versus TTTY1-high in LGG.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTTY1→partner) and Y-score (partner→TTTY1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	MICAL1 →	+7.977	+0.039	.007	<.001	3	2
BRCA	CSTF1 →	+9.057	+0.039	.003	<.001	3	2
BRCA	KCNMA1 →	+7.057	+0.013	.009	<.001	3	2
BRCA	PAX2 →	+9.057	+0.034	.003	<.001	3	2
BRCA	CDKL5 →	+7.473	+0.017	.007	<.001	3	2
STAD	NAPEPLD →	+5.226	+0.033	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 138 associations by consensus.

MICAL1 by TTTY1 expression — LGG

Explore this box plot interactively →