TTR

Across TCGA patient cohorts, TTR RNA expression is significantly associated with the go_rna of many other GO terms, with 6,985 significant associations in total. TGCT shows the largest number of these associations.

The most reproducible TTR-associated GO terms across cancer lineages are Regulation of very-low-density lipoprotein particle remodeling, ATP synthesis coupled electron transport, and Proton motive force-driven ATP synthesis. Each is linked with TTR in more than 13 cancer types. Because this analysis shows association rather than direction, both TTR-to-partner and partner-to-TTR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of very-low-density lipoprotein particle remodeling grouped by TTR-low versus TTR-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TTR→partner) and Y-score (partner→TTR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Regulation of very-low-density lipoprotein particle remodeling →	+0.710	+1.077	<.001	<.001	3	14
ESCA	ATP synthesis coupled electron transport →	+0.050	+0.991	.005	.002	2	13
STAD	Proton motive force-driven ATP synthesis →	+0.048	+0.978	.001	.001	2	13
STAD	Obsolete neurotransmitter catabolic process →	+0.065	+1.026	<.001	<.001	3	12
STAD	Oxidative phosphorylation →	+0.046	+1.095	.001	<.001	2	12
ESCA	Mitochondrial electron transport, NADH to ubiquinone →	+0.065	+1.171	.002	.001	2	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,985 associations by consensus.

Regulation of very-low-density lipoprotein particle remodeling by TTR expression — ESCA

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