TTR

Across TCGA pan-cancer cohorts, TTR RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TTR’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where TTR RNA is repressed in tumor relative to normal tissue. In most cancer types TTR is over-expressed in tumor, although a few such as KIRP and KIRC show the opposite, repressed pattern.

KIRP, KIRC, and COAD are the cancer types where TTR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TTR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Male	II,III,IV	−1.840	<.001	11	view →
KIRC	Male	IV	−1.487	<.001	11	view →
COAD	All	III,IV	−1.121	<.001	9	view →
THCA	All	All	−0.062	<.001	9	view →
LIHC	Female	All	−3.198	<.001	8	view →
CHOL	All	All	−7.702	<.001	5	view →
READ	All	All	−1.348	<.001	5	view →
KICH	All	All	+1.930	.001	4	view →
HNSC	Male	All	−0.140	.001	4	view →
UCEC	All	III,IV	−0.113	.033	4	view →
BRCA	All	All	+0.051	.010	4	view →
PRAD	All	All	+0.373	.044	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TTR–KIRP

Open the KIRP breakdown →