TTR

Across TCGA patient cohorts, TTR protein abundance is significantly associated with the RNA expression of many other genes, with 14,226 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible TTR-associated genes across cancer lineages are MGP, CCN2, and F13A1. Each is linked with TTR in more than 6 cancer types. Because this analysis shows association rather than direction, both TTR-to-partner and partner-to-TTR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TTR versus MGP in COAD, with a Pearson correlation of 0.44.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTR→partner) and Y-score (partner→TTR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MGP →	+1.667	+0.508	<.001	<.001	3	7
BRCA	CCN2 →	+1.208	+0.440	<.001	.009	3	7
GBM	F13A1 →	+1.488	+0.384	<.001	<.001	3	7
OV	ZEB1 →	+1.089	+0.761	<.001	<.001	3	7
BRCA	JAM2 →	+0.789	+0.615	<.001	<.001	3	7
CCRCC	ERG →	+0.795	+0.525	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,226 associations by consensus.

TTR vs MGP — COAD

Explore this scatter interactively →