TTPA

Across TCGA patient cohorts, TTPA mutation is significantly associated with the RNA expression of many other genes, with 436 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTPA-associated genes across cancer lineages are OR2AD1P, C1DP3, and GAPDHP29. Each is linked with TTPA in more than 1 cancer types. Because this analysis shows association rather than direction, both TTPA-to-partner and partner-to-TTPA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2AD1P grouped by TTPA-low versus TTPA-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTPA→partner) and Y-score (partner→TTPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	OR2AD1P →	+0.023	+4.147	.002	.008	3	2
LUAD	C1DP3 →	+0.214	+5.217	<.001	.007	3	2
UCEC	GAPDHP29 →	+0.232	+2.855	.007	.004	3	2
UCEC	TSPY8 →	+0.010	+5.606	<.001	<.001	3	2
LUSC	GAGE2E →	+0.160	+3.252	<.001	.006	3	2
UCEC	POM121C →	+0.621	+3.346	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 436 associations by consensus.

OR2AD1P by TTPA expression — SKCM

Explore this box plot interactively →