TTPA

Across TCGA pan-cancer cohorts, TTPA RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of TTPA’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TTPA RNA is repressed in tumor relative to normal tissue. In most cancer types TTPA is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and LUAD are the cancer types where TTPA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TTPA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	−1.054	<.001	12	view →
KIRP	Male	II,III,IV	−1.093	<.001	9	view →
LUAD	Female	II,III,IV	−1.013	<.001	9	view →
KICH	Female	II,III,IV	−1.201	<.001	8	view →
LUSC	Female	II,III,IV	−1.050	<.001	8	view →
BRCA	Female	All	−0.899	<.001	6	view →
CHOL	Male	All	−3.836	<.001	5	view →
LIHC	Female	All	−2.064	<.001	4	view →
HNSC	Female	All	−0.070	.025	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

TTPA–KIRC

Open the KIRC breakdown →