TTPA

Across TCGA cell cohorts, TTPA mutation is significantly associated with the mutation status of many other genes, with 923 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TTPA-associated genes across cancer lineages are UTP20, MAB21L1, and FBXL7. Each is linked with TTPA in more than 2 cancer types. Because this analysis shows association rather than direction, both TTPA-to-partner and partner-to-TTPA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UTP20 grouped by TTPA-low versus TTPA-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTPA→partner) and Y-score (partner→TTPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	UTP20 →	+3.169	+4.548	.004	.004	1	3
SKIN	MAB21L1 →	+4.392	+4.392	.009	.009	1	3
SKIN	FBXL7 →	+4.392	+5.357	<.001	<.001	1	3
SKIN	RALGAPA2 →	+2.807	+4.247	.007	.007	1	3
SKIN	TLR2 →	+4.392	+4.392	.009	.009	1	3
LARGE_INTESTINE	MARCO →	+3.007	+3.584	.008	.008	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 923 associations by consensus.

UTP20 by TTPA expression — SKIN

Explore this box plot interactively →