TTN

Across TCGA patient cohorts, TTN mutation is significantly associated with the RNA expression of many other genes, with 18,890 significant associations in total. STAD shows the largest number of these associations.

The most reproducible TTN-associated genes across cancer lineages are SHCBP1, FAM136A, and MCM10. Each is linked with TTN in more than 12 cancer types. Because this analysis shows association rather than direction, both TTN-to-partner and partner-to-TTN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SHCBP1 grouped by TTN-low versus TTN-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTN→partner) and Y-score (partner→TTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	SHCBP1 →	+0.482	+0.800	<.001	<.001	3	13
STAD	FAM136A →	+0.449	+1.230	<.001	<.001	3	13
LUAD	MCM10 →	+0.668	+1.085	<.001	<.001	3	13
LUAD	UBE2S →	+0.642	+0.855	<.001	<.001	3	12
STAD	EXO1 →	+0.669	+1.180	<.001	<.001	3	12
STAD	MELK →	+0.805	+1.338	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,890 associations by consensus.

SHCBP1 by TTN expression — STAD

Explore this box plot interactively →