TTN

Across TCGA pan-cancer cohorts, TTN RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated TTN data layer compared with 20 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher TTN RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TTN expression acts as an unfavorable survival marker, although some lineages such as GBM and UCS show a favorable association.

LUSC, KIRC, and ACC are the cancer types where TTN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Median	II,III,IV	0.475	0.843	<.001	45	view →
KIRC	DFS	Tertile	IV	0.179	0.460	.002	40	view →
ACC	DFS	Tertile	IV	0.108	0.488	.007	33	view →
UVM	DFS	Quartile	III,IV	0.273	0.914	.004	29	view →
STAD	DFS	Quartile	All	0.399	0.636	.009	16	view →
GBM	DFS	Quartile	All	0.501	0.212	.014	12	view →
KIRP	DFS	Median	All	0.473	0.698	.020	12	view →
SCLC	OS	Tertile	All	0.247	0.658	.023	9	view →
KICH	OS	Tertile	III,IV	0.194	0.801	.023	9	view →
READ	DFS	Tertile	IV	0.179	0.936	.024	7	view →
UCS	DFS	Median	II,III,IV	0.573	0.290	.021	6	view →
COAD	OS	Quartile	IV	0.490	0.893	.026	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

TTN–LUSC (DFS)

Open the LUSC breakdown →