TTN

Across TCGA cell cohorts, TTN RNA expression is significantly associated with the go_rna of many other GO terms, with 2,697 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible TTN-associated GO terms across cancer lineages are Signal transduction in response to DNA damage, RNA localization, and Regulation of chromosome organization. Each is linked with TTN in more than 10 cancer types. Because this analysis shows association rather than direction, both TTN-to-partner and partner-to-TTN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Signal transduction in response to DNA damage grouped by TTN-low versus TTN-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TTN→partner) and Y-score (partner→TTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Signal transduction in response to DNA damage →	+0.069	+0.121	<.001	.001	3	11
UPPER_AERODIGESTIVE_TRACT	RNA localization →	+0.090	+0.180	<.001	<.001	3	11
BREAST	Regulation of chromosome organization →	+0.090	+0.145	<.001	.007	3	10
SOFT_TISSUE	mRNA transport →	+0.096	+2.166	<.001	.001	3	10
BLOOD_Leukemia	Viral translational termination-reinitiation →	+0.091	+0.352	<.001	.003	3	10
UPPER_AERODIGESTIVE_TRACT	Late viral transcription →	+0.110	+0.151	.006	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,697 associations by consensus.

Signal transduction in response to DNA damage by TTN expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →