TTLL9

Across TCGA patient cohorts, TTLL9 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTLL9-associated genes across cancer lineages are ATM, c-Kit, and 14-3-3_beta. Each is linked with TTLL9 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTLL9-to-partner and partner-to-TTLL9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by TTLL9-low versus TTLL9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTLL9→partner) and Y-score (partner→TTLL9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.514	-2.115	<.001	.017	3	2
SKCM	c-Kit →	-0.758	-3.000	.033	.035	3	2
UCEC	14-3-3_beta →	-0.119	-3.973	<.001	<.001	3	1
UCEC	EGFR_pY1068 →	-0.244	-1.874	.003	.002	3	1
UCEC	EGFR →	-0.154	-2.222	.003	.010	3	1
UCEC	A-Raf_pS299 →	-0.100	-1.807	.012	.025	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

ATM by TTLL9 expression — UCEC

Explore this box plot interactively →