TTLL9

Across TCGA pan-cancer cohorts, TTLL9 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of TTLL9’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where TTLL9 RNA is repressed in tumor relative to normal tissue. In most cancer types TTLL9 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, COAD, and KIRC are the cancer types where TTLL9 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TTLL9 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	III,IV	−0.467	<.001	10	view →
COAD	Female	All	+0.101	<.001	10	view →
KIRC	All	II,III,IV	−0.207	<.001	9	view →
LUAD	All	II,III,IV	−0.702	<.001	8	view →
THCA	Male	All	−0.555	<.001	8	view →
LUSC	Male	II,III,IV	−0.915	<.001	6	view →
BRCA	All	II,III,IV	+0.247	.002	4	view →
STAD	All	All	+0.133	.009	3	view →
CHOL	All	All	+0.323	.003	2	view →
PRAD	All	All	−0.105	.008	2	view →
LIHC	All	All	+0.013	.020	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

TTLL9–KICH

Open the KICH breakdown →