TTLL9

Across TCGA cell cohorts, TTLL9 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TTLL9-associated genes across cancer lineages are SLC7A13, HELT, and CBLIF. Each is linked with TTLL9 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTLL9-to-partner and partner-to-TTLL9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC7A13 grouped by TTLL9-low versus TTLL9-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTLL9→partner) and Y-score (partner→TTLL9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SLC7A13 →	+0.066	+6.357	<.001	<.001	3	1
CNS	HELT →	+0.037	+5.321	<.001	.005	3	1
BLOOD_Leukemia	CBLIF →	+0.074	+3.091	<.001	.006	3	1
BLOOD_Leukemia	SLC22A7 →	+0.029	+3.266	.004	.003	3	1
BLOOD_Leukemia	CYP2C19 →	+0.016	+2.982	<.001	.007	3	1
BLOOD_Leukemia	WFIKKN2 →	+0.014	+4.954	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

SLC7A13 by TTLL9 expression — CNS

Explore this box plot interactively →