TTLL7

Across TCGA patient cohorts, TTLL7 mutation is significantly associated with the RNA expression of many other genes, with 4,322 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTLL7-associated genes across cancer lineages are SPATA5L1, PIGW, and TRAIP. Each is linked with TTLL7 in more than 4 cancer types. Because this analysis shows association rather than direction, both TTLL7-to-partner and partner-to-TTLL7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA5L1 grouped by TTLL7-low versus TTLL7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTLL7→partner) and Y-score (partner→TTLL7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SPATA5L1 →	+0.355	+1.638	<.001	<.001	3	5
UCEC	PIGW →	+0.463	+2.220	<.001	<.001	3	4
UCEC	TRAIP →	+0.445	+1.660	<.001	<.001	3	4
UCEC	DNAJA3 →	+0.386	+1.660	<.001	<.001	3	4
UCEC	RFC5 →	+0.398	+1.785	<.001	.001	3	4
UCEC	ZWINT →	+0.639	+1.918	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,322 associations by consensus.

SPATA5L1 by TTLL7 expression — UCEC

Explore this box plot interactively →