TTLL7-IT1

Across TCGA pan-cancer cohorts, TTLL7-IT1 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of TTLL7-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where TTLL7-IT1 RNA is repressed in tumor relative to normal tissue. In most cancer types TTLL7-IT1 is over-expressed in tumor, although a few such as KICH and PAAD show the opposite, repressed pattern.

KICH, PAAD, and LUSC are the cancer types where TTLL7-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TTLL7-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	III,IV	−0.033	<.001	4	view →
PAAD	Female	All	−0.110	.031	2	view →
LUSC	All	III,IV	−0.031	.014	2	view →
THCA	Female	All	−0.027	<.001	2	view →
LIHC	All	All	+0.016	.015	2	view →
KIRC	All	II,III,IV	+0.010	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

TTLL7-IT1–KICH

Open the KICH breakdown →