TTLL6

Across TCGA patient cohorts, TTLL6 mutation is significantly associated with the RNA expression of many other genes, with 2,679 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTLL6-associated genes across cancer lineages are CPE, SNORA70D, and HNRNPCP1. Each is linked with TTLL6 in more than 2 cancer types. Because this analysis shows association rather than direction, both TTLL6-to-partner and partner-to-TTLL6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CPE grouped by TTLL6-low versus TTLL6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTLL6→partner) and Y-score (partner→TTLL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CPE →	-0.852	-1.584	<.001	.004	3	3
LUAD	SNORA70D →	+1.112	+4.926	<.001	.002	3	3
UCEC	HNRNPCP1 →	+0.440	+2.099	<.001	<.001	3	3
UCEC	PDGFD →	-0.689	-1.762	<.001	<.001	3	3
CESC	RNU6-813P →	+0.497	+5.539	<.001	.004	3	2
LUSC	RNU6-1019P →	+0.679	+3.494	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,679 associations by consensus.

CPE by TTLL6 expression — UCEC

Explore this box plot interactively →