TTLL12

Across TCGA pan-cancer cohorts, TTLL12 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TTLL12 data layer compared with 30 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TTLL12 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TTLL12 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

LUAD, CCRCC, and PDAC are the cancer types where TTLL12 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	II,III,IV	0.336	1.000	<.001	31	view →
CCRCC	DFS	Median	III,IV	0.981	0.749	.014	8	view →
PDAC	DFS	Quartile	II,III,IV	0.829	0.656	.031	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

TTLL12–LUAD (OS)

Open the LUAD breakdown →