TTLL12

Across TCGA pan-cancer cohorts, TTLL12 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of TTLL12’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where TTLL12 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TTLL12 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

KIRP, LUSC, and LUAD are the cancer types where TTLL12 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TTLL12 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Female	II,III,IV	+1.142	<.001	11	view →
LUSC	All	III,IV	+2.481	<.001	9	view →
LUAD	Female	III,IV	+1.178	<.001	9	view →
LIHC	Male	All	+1.034	<.001	9	view →
THCA	Female	All	−0.357	<.001	8	view →
KIRC	Female	All	+0.402	<.001	7	view →
BRCA	All	III,IV	+1.446	<.001	6	view →
HNSC	Male	All	+0.897	.001	5	view →
BLCA	Male	All	+0.822	.007	5	view →
PAAD	All	All	+1.095	.003	4	view →
KICH	Female	All	−0.720	<.001	4	view →
COAD	All	All	+0.314	.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

TTLL12–KIRP

Open the KIRP breakdown →