TTLL12

Across TCGA patient cohorts, TTLL12 mutation is significantly associated with the RNA expression of many other genes, with 3,861 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTLL12-associated genes across cancer lineages are OIP5, PIK3R3, and C12orf65. Each is linked with TTLL12 in more than 2 cancer types. Because this analysis shows association rather than direction, both TTLL12-to-partner and partner-to-TTLL12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OIP5 grouped by TTLL12-low versus TTLL12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTLL12→partner) and Y-score (partner→TTLL12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OIP5 →	+0.679	+2.343	.002	<.001	3	3
UCEC	PIK3R3 →	+0.672	+2.095	.002	.003	3	3
COAD	C12orf65 →	+0.424	+3.362	<.001	.004	3	3
UCEC	PSMC3IP →	+0.647	+2.439	<.001	.001	3	3
UCEC	NUSAP1 →	+0.763	+3.032	<.001	<.001	3	3
UCEC	CSNK1G1 →	+0.569	+3.818	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,861 associations by consensus.

OIP5 by TTLL12 expression — UCEC

Explore this box plot interactively →