TTLL12

Across TCGA cell cohorts, TTLL12 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TTLL12-associated genes across cancer lineages are PRSS58, AVP, and HCN4. Each is linked with TTLL12 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTLL12-to-partner and partner-to-TTLL12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRSS58 grouped by TTLL12-low versus TTLL12-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTLL12→partner) and Y-score (partner→TTLL12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PRSS58 →	+0.239	+4.930	<.001	.008	3	1
LARGE_INTESTINE	AVP →	+0.048	+3.217	<.001	.006	3	1
LARGE_INTESTINE	HCN4 →	+0.131	+3.333	.007	.009	3	1
LARGE_INTESTINE	BPIFB6 →	+0.014	+3.700	<.001	.009	3	1
LARGE_INTESTINE	OR10W1 →	+0.014	+3.562	<.001	.002	3	1
LARGE_INTESTINE	OR10Q1 →	+0.077	+3.242	.009	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

PRSS58 by TTLL12 expression — SOFT_TISSUE

Explore this box plot interactively →