TTLL11

Across TCGA patient cohorts, TTLL11 mutation is significantly associated with the RNA expression of many other genes, with 2,318 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTLL11-associated genes across cancer lineages are SLC7A11, GTSE1, and AUNIP. Each is linked with TTLL11 in more than 2 cancer types. Because this analysis shows association rather than direction, both TTLL11-to-partner and partner-to-TTLL11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC7A11 grouped by TTLL11-low versus TTLL11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTLL11→partner) and Y-score (partner→TTLL11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SLC7A11 →	+0.768	+1.716	<.001	.004	3	3
UCEC	GTSE1 →	+0.636	+2.431	<.001	.001	3	3
UCEC	AUNIP →	+0.555	+2.617	.002	.005	3	3
UCEC	YARS1 →	+0.425	+2.194	<.001	.001	3	3
SKCM	BPNT2P →	+0.062	+3.076	<.001	.001	3	2
SKCM	RNU6-48P →	+0.623	+3.881	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,318 associations by consensus.

SLC7A11 by TTLL11 expression — UCEC

Explore this box plot interactively →