TTLL11

Across TCGA pan-cancer cohorts, TTLL11 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TTLL11’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where TTLL11 RNA is repressed in tumor relative to normal tissue. In most cancer types TTLL11 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and BLCA are the cancer types where TTLL11 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TTLL11 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−0.829	<.001	10	view →
THCA	Male	III,IV	−0.667	<.001	9	view →
BLCA	All	III,IV	−0.981	<.001	8	view →
LUAD	All	II,III,IV	−0.485	<.001	7	view →
UCEC	All	All	−0.860	<.001	6	view →
LUSC	Female	All	−0.727	<.001	6	view →
BRCA	Female	All	−0.495	<.001	6	view →
LIHC	All	II,III,IV	+0.477	<.001	6	view →
HNSC	Female	IV	+0.544	.020	2	view →
READ	All	III,IV	−0.509	.010	2	view →
KIRC	All	II,III,IV	−0.186	.024	2	view →
CHOL	All	All	+0.625	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TTLL11–KICH

Open the KICH breakdown →