TTLL11

Across TCGA patient cohorts, TTLL11 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTLL11-associated genes across cancer lineages are PCNA, ATM, and NDRG1_pT346. Each is linked with TTLL11 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTLL11-to-partner and partner-to-TTLL11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by TTLL11-low versus TTLL11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTLL11→partner) and Y-score (partner→TTLL11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.225	+2.201	.001	<.001	3	2
UCEC	ATM →	-0.559	-2.201	<.001	<.001	3	2
COAD	NDRG1_pT346 →	+0.545	+2.815	.041	.036	3	1
UCEC	eEF2 →	+0.260	+2.321	.030	.033	3	1
UCEC	EGFR →	-0.139	-3.143	.009	.018	3	1
UCEC	ERK2 →	+0.196	+1.847	.002	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

PCNA by TTLL11 expression — UCEC

Explore this box plot interactively →