TTLL11

Across TCGA cell cohorts, TTLL11 mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TTLL11-associated genes across cancer lineages are SCGB1D2, PIK3R3, and VHL. Each is linked with TTLL11 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTLL11-to-partner and partner-to-TTLL11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCGB1D2 grouped by TTLL11-low versus TTLL11-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTLL11→partner) and Y-score (partner→TTLL11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SCGB1D2 →	+0.518	+2.527	.002	.006	3	2
LARGE_INTESTINE	PIK3R3 →	+1.374	+3.067	<.001	.009	3	1
LARGE_INTESTINE	VHL →	+0.721	+3.067	.003	.009	3	1
LARGE_INTESTINE	TUBA3E →	+0.098	+3.591	.001	.002	3	1
LARGE_INTESTINE	NBPF20 →	+0.708	+3.064	<.001	.009	3	1
LARGE_INTESTINE	CPLX4 →	+0.029	+3.222	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

SCGB1D2 by TTLL11 expression — LARGE_INTESTINE

Explore this box plot interactively →