TTLL11-IT1

Across TCGA pan-cancer cohorts, TTLL11-IT1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TTLL11-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TTLL11-IT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TTLL11-IT1 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

HNSC, KIRC, and KICH are the cancer types where TTLL11-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TTLL11-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+1.276	<.001	12	view →
KIRC	Male	II,III,IV	−0.349	<.001	12	view →
KICH	Male	All	−0.617	<.001	8	view →
LUAD	Female	All	+0.604	<.001	8	view →
LIHC	All	II,III,IV	+0.051	.001	8	view →
THCA	Female	All	+0.199	<.001	7	view →
UCEC	All	All	+0.293	.004	6	view →
LUSC	All	All	+0.268	<.001	5	view →
KIRP	All	All	−0.214	.001	4	view →
CHOL	All	II,III,IV	+0.095	.002	3	view →
BLCA	All	III,IV	+0.195	.031	2	view →
READ	Female	All	+0.146	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TTLL11-IT1–HNSC

Open the HNSC breakdown →