TTLL10

Across TCGA patient cohorts, TTLL10 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTLL10-associated genes across cancer lineages are eIF4E, JNK2, and MSH2. Each is linked with TTLL10 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTLL10-to-partner and partner-to-TTLL10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by TTLL10-low versus TTLL10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTLL10→partner) and Y-score (partner→TTLL10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.249	+2.247	.001	.001	3	2
UCEC	JNK2 →	+0.189	+2.469	.009	.010	3	2
UCEC	MSH2 →	-0.235	-2.433	.005	.018	3	2
UCEC	PDCD4 →	-0.524	-3.584	.002	.002	3	2
UCEC	ATM →	-0.736	-3.794	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.705	+2.242	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

eIF4E by TTLL10 expression — UCEC

Explore this box plot interactively →