TTLL10

Across TCGA pan-cancer cohorts, TTLL10 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated TTLL10 data layer compared with 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TTLL10 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TTLL10 expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRC show a favorable association.

HNSC, KIRC, and READ are the cancer types where TTLL10 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.762	0.613	<.001	108	view →
KIRC	DFS	Tertile	All	0.731	0.525	<.001	104	view →
READ	DFS	Tertile	III,IV	0.242	0.714	.001	52	view →
LUAD	DFS	Tertile	All	0.880	0.735	.001	48	view →
LUSC	OS	Median	III,IV	0.781	0.572	.008	37	view →
LIHC	DFS	Quartile	III,IV	0.590	0.214	.005	32	view →
THYM	DFS	Median	All	0.946	0.784	.003	26	view →
SCLC	DFS	Median	II,III,IV	0.488	0.165	.004	24	view →
UCEC	OS	Quartile	All	0.990	0.911	<.001	22	view →
PRAD	DFS	Median	All	0.831	0.928	<.001	18	view →
CHOL	DFS	Median	All	0.600	0.221	.019	17	view →
THCA	OS	Median	II,III,IV	1.000	0.629	.007	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

TTLL10–HNSC (DFS)

Open the HNSC breakdown →