TTLL10

Across TCGA cell cohorts, TTLL10 mutation is significantly associated with the RNA expression of many other genes, with 364 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TTLL10-associated genes across cancer lineages are PAX9, KSR2, and TBC1D28. Each is linked with TTLL10 in more than 1 cancer types. Because this analysis shows association rather than direction, both TTLL10-to-partner and partner-to-TTLL10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PAX9 grouped by TTLL10-low versus TTLL10-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTLL10→partner) and Y-score (partner→TTLL10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PAX9 →	+1.000	+3.212	<.001	.006	3	2
BLOOD_Leukemia	KSR2 →	+0.407	+3.798	<.001	.004	3	2
BLOOD_Leukemia	TBC1D28 →	+0.084	+3.926	<.001	.003	3	2
BLOOD_Myeloma	HTR2A →	+0.133	+4.807	<.001	.006	3	1
BLOOD_Myeloma	AKAP4 →	+0.056	+4.807	<.001	.006	3	1
BLOOD_Myeloma	PRG3 →	+0.026	+4.807	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 364 associations by consensus.

PAX9 by TTLL10 expression — LARGE_INTESTINE

Explore this box plot interactively →