TTLL1-AS1

Across TCGA pan-cancer cohorts, TTLL1-AS1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated TTLL1-AS1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TTLL1-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated TTLL1-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BLCA show a favorable association.

HNSC, ACC, and KIRC are the cancer types where TTLL1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.468	0.254	.001	98	view →
ACC	DFS	Median	All	0.231	0.675	<.001	96	view →
KIRC	DFS	Quartile	III,IV	0.333	0.612	<.001	77	view →
BLCA	DFS	Quartile	All	0.604	0.451	.008	51	view →
LGG	DFS	Median	All	0.482	0.315	<.001	47	view →
LIHC	OS	Tertile	All	0.669	0.857	.001	46	view →
MESO	DFS	Median	All	0.660	0.239	.003	18	view →
UCS	OS	Quartile	All	0.665	0.323	.031	16	view →
UVM	OS	Median	III,IV	0.971	0.567	.004	14	view →
KICH	OS	Quartile	All	0.552	1.000	.011	13	view →
LAML	DFS	Median	All	0.521	0.234	.001	12	view →
CHOL	DFS	Tertile	All	0.243	0.740	.023	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

TTLL1-AS1–HNSC (OS)

Open the HNSC breakdown →