TTLL1-AS1

Across TCGA pan-cancer cohorts, TTLL1-AS1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of TTLL1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TTLL1-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types TTLL1-AS1 is over-expressed in tumor, although a few such as KIRC and UCEC show the opposite, repressed pattern.

KIRC, LIHC, and UCEC are the cancer types where TTLL1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TTLL1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	II,III,IV	−0.141	<.001	9	view →
LIHC	Female	II,III,IV	+0.122	<.001	9	view →
UCEC	All	III,IV	−0.591	<.001	8	view →
THCA	Male	III,IV	−0.552	<.001	8	view →
LUAD	Female	II,III,IV	−0.239	<.001	6	view →
BRCA	Female	All	−0.157	<.001	6	view →
BLCA	Male	IV	−0.777	.009	3	view →
CHOL	Male	All	+0.658	<.001	3	view →
COAD	All	All	−0.108	.011	3	view →
KICH	All	All	−0.160	.007	2	view →
LUSC	Male	All	−0.132	.007	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

TTLL1-AS1–KIRC

Open the KIRC breakdown →