TTL

Across TCGA patient cohorts, TTL RNA expression is significantly associated with the protein abundance of many other proteins, with 18,442 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TTL-associated proteins across cancer lineages are CLASP1, MCM2, and MCM6. Each is linked with TTL in more than 6 cancer types. Because this analysis shows association rather than direction, both TTL-to-partner and partner-to-TTL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TTL versus CLASP1 in LSCC, with a Pearson correlation of 0.62.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TTL→partner) and Y-score (partner→TTL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CLASP1 →	+0.271	+0.545	<.001	<.001	3	7
LUAD	MCM2 →	+0.494	+0.454	<.001	<.001	3	6
GBM	MCM6 →	+0.710	+0.352	.001	.005	3	6
LUAD	PBLD →	-0.847	-0.408	<.001	<.001	3	6
LUAD	CCNB1 →	+0.857	+0.454	<.001	<.001	3	6
LUAD	DBN1 →	+0.482	+0.572	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,442 associations by consensus.

TTL vs CLASP1 — LSCC

Explore this scatter interactively →