TTL

Across TCGA cell cohorts, TTL RNA expression is significantly associated with the go_rna of many other GO terms, with 5,104 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TTL-associated GO terms across cancer lineages are Regulation of metaphase/anaphase transition of cell cycle, Microtubule cytoskeleton organization involved in mitosis, and Regulation of microtubule-based process. Each is linked with TTL in more than 14 cancer types. Because this analysis shows association rather than direction, both TTL-to-partner and partner-to-TTL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of metaphase/anaphase transition of cell cycle grouped by TTL-low versus TTL-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TTL→partner) and Y-score (partner→TTL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of metaphase/anaphase transition of cell cycle →	+0.120	+1.004	.001	.001	3	15
UPPER_AERODIGESTIVE_TRACT	Microtubule cytoskeleton organization involved in mitosis →	+0.098	+1.116	.001	.001	3	15
LUNG_NSCLC_LUSC	Regulation of microtubule-based process →	+0.063	+1.031	<.001	.002	3	15
UPPER_AERODIGESTIVE_TRACT	Nuclear transport →	+0.066	+1.165	.002	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Regulation of chromosome segregation →	+0.129	+1.183	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Nucleocytoplasmic transport →	+0.066	+1.243	.002	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,104 associations by consensus.

Regulation of metaphase/anaphase transition of cell cycle by TTL expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →