TTL

Across TCGA cell cohorts, TTL mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TTL-associated genes across cancer lineages are NLRP8, KRTAP12-3, and USP17L3. Each is linked with TTL in more than 1 cancer types. Because this analysis shows association rather than direction, both TTL-to-partner and partner-to-TTL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NLRP8 grouped by TTL-low versus TTL-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTL→partner) and Y-score (partner→TTL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	NLRP8 →	+0.026	+4.977	<.001	.007	3	1
BLOOD_Leukemia	KRTAP12-3 →	+0.124	+5.539	<.001	.003	3	1
BLOOD_Leukemia	USP17L3 →	+0.012	+4.922	.009	.009	3	1
LARGE_INTESTINE	PLPPR1 →	+0.559	+3.507	<.001	.002	3	1
LARGE_INTESTINE	MFSD14A →	+0.514	+3.064	.005	.009	3	1
LARGE_INTESTINE	CHRM1 →	+0.761	+3.241	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

NLRP8 by TTL expression — SKIN

Explore this box plot interactively →