TTK

Across TCGA pan-cancer cohorts, TTK mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of TTK’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TTK mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types TTK is over-expressed in tumor.

HNSC, LSCC, and LUAD are the cancer types where TTK tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TTK mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.534	<.001	11	view →
LSCC	Male	II,III,IV	+0.983	<.001	9	view →
LUAD	Male	All	+0.804	<.001	7	view →
CCRCC	All	II,III,IV	+0.558	.045	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

TTK–HNSC

Open the HNSC breakdown →