TTI1

Across TCGA pan-cancer cohorts, TTI1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TTI1 data layer compared with 28 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher TTI1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TTI1 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

CCRCC, PDAC, and LSCC are the cancer types where TTI1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	All	0.730	0.951	.001	25	view →
PDAC	OS	Quartile	II,III,IV	0.211	0.637	.005	24	view →
LSCC	OS	Tertile	II,III,IV	0.891	0.512	.005	11	view →
LUAD	DFS	Median	All	0.524	0.886	.009	5	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TTI1–CCRCC (OS)

Open the CCRCC breakdown →