TTC9C

Across TCGA cell cohorts, TTC9C RNA expression is significantly associated with the go_rna of many other GO terms, with 2,963 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TTC9C-associated GO terms across cancer lineages are Regulation of protein K48-linked ubiquitination, Co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway, and Hormone metabolic process. Each is linked with TTC9C in more than 7 cancer types. Because this analysis shows association rather than direction, both TTC9C-to-partner and partner-to-TTC9C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein K48-linked ubiquitination grouped by TTC9C-low versus TTC9C-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC9C→partner) and Y-score (partner→TTC9C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of protein K48-linked ubiquitination →	+0.120	+0.533	.008	.003	3	8
UPPER_AERODIGESTIVE_TRACT	Co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway →	+0.099	+0.534	<.001	<.001	3	8
LUNG_NSCLC_LUAD	Hormone metabolic process →	-0.122	-0.472	<.001	.005	3	8
BLOOD_Lymphoma	Organelle inheritance →	+0.087	+0.479	<.001	.003	3	8
BLOOD_Lymphoma	Golgi inheritance →	+0.087	+0.479	<.001	.003	3	8
LUNG_NSCLC_LUSC	Response to toxic substance →	-0.099	-1.390	.001	.006	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,963 associations by consensus.

Regulation of protein K48-linked ubiquitination by TTC9C expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →