TTC8

Across TCGA pan-cancer cohorts, TTC8 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TTC8 data layer compared with 26 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher TTC8 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TTC8 expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

COAD, KICH, and UCEC are the cancer types where TTC8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.464	0.876	<.001	28	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
UCEC	DFS	Median	All	0.964	0.624	.014	8	view →
STAD	DFS	Median	III,IV	1.000	0.337	.041	5	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TTC8–COAD (OS)

Open the COAD breakdown →