TTC8

Across TCGA pan-cancer cohorts, TTC8 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TTC8 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TTC8 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TTC8 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

UCEC, LSCC, and HNSC are the cancer types where TTC8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	III,IV	0.433	1.000	.007	10	view →
LSCC	DFS	Median	II,III,IV	0.841	1.000	.008	7	view →
HNSC	OS	Quartile	IV	0.902	0.551	.012	5	view →
LUAD	OS	Median	All	0.688	0.849	.036	1	view →
CCRCC	DFS	Quartile	III,IV	1.000	0.767	.023	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TTC8–UCEC (OS)

Open the UCEC breakdown →