TTC7B

Across TCGA pan-cancer cohorts, TTC7B mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated TTC7B data layer compared with 24 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TTC7B mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TTC7B expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

LUAD, CCRCC, and PDAC are the cancer types where TTC7B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	III,IV	0.247	0.805	.001	50	view →
CCRCC	DFS	Quartile	III,IV	0.853	0.410	<.001	28	view →
PDAC	OS	Median	IV	0.951	0.381	.006	16	view →
HNSC	DFS	Quartile	II,III,IV	0.898	0.675	.012	10	view →
UCEC	OS	Tertile	III,IV	0.346	1.000	.018	10	view →
GBM	DFS	Tertile	All	0.781	0.626	.032	4	view →
LSCC	DFS	Tertile	All	0.848	1.000	.031	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

TTC7B–LUAD (DFS)

Open the LUAD breakdown →