TTC7A

Across TCGA patient cohorts, TTC7A mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TTC7A-associated genes across cancer lineages are Bax, Lck, and MEK1. Each is linked with TTC7A in more than 2 cancer types. Because this analysis shows association rather than direction, both TTC7A-to-partner and partner-to-TTC7A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bax grouped by TTC7A-low versus TTC7A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC7A→partner) and Y-score (partner→TTC7A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Bax →	+0.170	+1.362	.044	.037	3	3
COAD	Lck →	+0.330	+3.025	.037	.019	3	2
UCEC	MEK1 →	+0.380	+2.392	.003	<.001	3	2
UCEC	14-3-3_beta →	-0.098	-1.673	.005	.040	3	2
UCEC	eEF2 →	+0.318	+1.362	.011	.037	3	2
UCEC	ERK2 →	+0.160	+3.459	.018	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

Bax by TTC7A expression — UCEC

Explore this box plot interactively →