TTC6

Across TCGA cell cohorts, TTC6 mutation is significantly associated with the RNA expression of many other genes, with 367 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TTC6-associated genes across cancer lineages are DAZ2, CT47A6, and WRN. Each is linked with TTC6 in more than 2 cancer types. Because this analysis shows association rather than direction, both TTC6-to-partner and partner-to-TTC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DAZ2 grouped by TTC6-low versus TTC6-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TTC6→partner) and Y-score (partner→TTC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	DAZ2 →	+0.064	+4.222	<.001	.006	3	2
OVARY	CT47A6 →	+0.018	+4.222	<.001	.006	3	2
LUNG_NSCLC_LUAD	WRN →	+0.508	+3.111	.006	.009	3	2
LARGE_INTESTINE	STXBP3 →	+0.517	+3.067	<.001	.009	3	2
LARGE_INTESTINE	DPH5 →	+0.616	+3.502	<.001	.001	3	2
LARGE_INTESTINE	SPATA6 →	+0.557	+3.371	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 367 associations by consensus.

DAZ2 by TTC6 expression — OVARY

Explore this box plot interactively →